As the old TV show House taught us, it there are a variety of medical problems there that we do not know. While Dr. House may be fiction, some of the diseases and conditions described on the show are too real.
The freakiest medical conditions may not be life threatening. They just happen to ruin people's quality of life. Take the condition known triphalangeal inch, for example.
The hands of those who suffer from triphalangeal inch (TPT) look like this.
Wikipedia
What we see here is that the thumb is malformed, what really prevents its range of motion.
Wikipedia
The thumbs of people TPT violations are not applicable. This means that people can not touch their thumbs to their fingers.
Reddit / churizurd
In some case, the thumb might look like a much smaller nub, or it might be completely absent.
Wikipedia
(via Reddit)
As you can imagine, this is an extremely rare condition. In fact, it affects one in 25,000 people. Doctors believe that TPT is at least partly hereditary, but researchers are still looking for other possible explanations.

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